Cabergoline in the Treatment of Male Orgasmic Disorder A Retrospective Pilot Analysis Sexual Medicine

ATLANTA — Anorgasmia improved or resolved completely in almost 70% of men treated with the dopamine receptor agonist cabergoline, results of a small retrospective study showed. High prolactin levels can cause changes in a woman’s ovulation, menstrual cycle, and breast milk production. In men, high prolactin levels can affect reproduction and cause sexual issues.

Cabergoline: Is It Good For Sexual Health?

Cabergoline has been used historically to treat sexual dysfunction, but not male orgasmic disorder, although its mechanism of action would seem reasonable for its use in treatment of men with orgasmic disorder. This study does have limitations that affect its generalizability to all men with orgasmic disorder. First, our study is not placebo controlled or randomized, introducing the possibility that the purported efficacy of cabergoline in this setting might be a placebo effect. Second, our sample is relatively small, limiting the generalizability of the study. In addition, a larger proportion of non-responders used testosterone compared with responders, and longitudinal testosterone data were not available for the entire cohort. Fourth, orgasmic symptoms were not assessed using a validated questionnaire, limiting our ability to assess the nature of symptomatic improvement while on cabergoline.

Men’s Health

Having a sex therapist available for referrals is an important consideration for providers since there can be issues with accessibility including long waiting lists and financial barriers since insurance coverage is variable. If such barriers to sex therapy exist, providers can begin by suggesting open discussions about sexual desires and preferences between the patient and their partner to facilitate treatment. Other low risk behavior modifications include erogenous zone stimulation, altering pressure and pace of penile stimulatory techniques, using vibrators, or incorporating roleplay.

  • Correlations were performed by calculating the Spearman’s coefficient.
  • Sildenafil (Viagra) helps people with erectile dysfunction (ED) last longer in sexual situations.
  • Mean age of men in the study was 63, which did not differ between responders and nonresponders.
  • So, the side effects of Cabergoline for men running steroids are unlikely to occur.
  • Cabergoline is usually taken twice each week for at least 6 months.
  • Along with its needed effects, cabergoline may cause some unwanted effects.

How is delayed ejaculation treated?

Your healthcare provider will ask you questions about your medical history, sexual habits and ejaculation patterns. They will rule out other conditions, possibly doing laboratory testing on hormones (testosterone), urine (pee) or semen. For instance, selective Parabolan 10 mg Hubei for bodybuilding serotonin reuptake inhibitors and classic antipsychotics that are not prolactin sparing have been shown to cause disturbances in orgasmic function. And as many as 75% of men have reported orgasmic dysfunction following radical prostatectomy, said Hsieh.

There are have been reports of increased sexual urges or other strong urges such as gambling while taking this medicine. If you experience any of these while taking this medicine, you should report this to your health care professional as soon as possible. “Cabergoline is an effective treatment option for male anorgasmia,” said Hsieh, of Baylor College of Medicine in Houston. “Further studies are needed to better understand the pathophysiology of anorgasmia and to validate our observations of cabergoline’s action in anorgasmic patients.” High levels of prolactin in the blood are referred to as hyperprolactinemia. In women, high levels of prolactin can cause symptoms such as irregular periods, unwanted breast milk, infertility, and breast tenderness.

There are estimates that 1% to 4% of men in the U.S. have delayed ejaculation. Other medications can affect the removal of cabergoline from your body, which may affect how cabergoline works. Examples include certain azole antifungals (such as itraconazole, ketoconazole, posaconazole), cobicistat, HIV protease inhibitors (such as saquinavir), ritonavir, among others. Nausea, vomiting, stomach upset, constipation, dizziness, lightheadedness, or tiredness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.